тесты по фармакологии 3на англ

TESTS for training

1.    A patient with symptoms of phosphorganic poisoning was taken to emergency department. Which of the following drugs must be used as a drug of first aid?

A.   Unithyolum

B.    Potassium chloride
С. Atropine
D.   Chlorpromazine (Aminazine)

E.   Glucose

2.   After abdominal surgery performed under general anaes thesia with non-depolarizing myorelaxant spontaneous respiration was not restored. Which of the following drugs is to be used as an antidote of non-depolarizing myorelaxant?

A.   Aceclidinum

B.   Pilocarpin

C.  Neostigmine (Proserin)

D.  Hyascine

E.   Isonitrosine

3.   A 5 years old child was taken to toxicological department with Belladonna poisoning. Alongside with peripheral manifestations the CNS symptoms were manifested. Which of the following agents has to be administered as an antidote?

A.   Aceclidin

B.   Pilocarpin

C.   Neostigmine (Proserin)

D.   Adrenaline

E.   Galantamine hydrobromide

4. A patient suffering from insomnia addressed his doctor. The main problem was in the difficulties with sleep onset. Doctor prescribed zolpidem. Which of the following characteristics is true for this agent?

A. It belongs to benzodiazepine derivatives

B.    It belongs to barbiturates

C.   It has the ability to cause quick onset of sleep

D.   It's poorly absorbed from GIT

E.   It poorly binds to protein

5. A 67 year-old male patient suffering from arthritis was treating himself with acetyl salicylic acid (aspirin). In 2 weeks patient addressed doctor complaining of pain in epigastric area. On examination of the patient doctor prescribed anti-inflammatory agent, selectively inhibiting COX-2. Point out this drug.
A.   Paracetamole

B.   Diclophenac-sodium

C.   Celecoxib

D.   Metamisole (Analginum)

E.   Indomethacine

6. In complex treatment of a patient with angina pectoris non-narcotic analgesic exerting antiplatelet activity was included. Point out this agent.
A.   Meperidine

B.    Morphine
С. Tramadol
D.   Metamizole

E.   Aspirin

7. A patient was treated for psychosis for 2 weeks. The psychic patient's condition improved but rigidity, tremor, and hypoki-nesia developed. Which of the drugs can cause such complications?

A.   Diazepam

B. Chlorpromazine (Aminazinum)

С. Amytriptiline

D.    Piracetam

E.   Chlordiazepoxide

8.    For treatment of hypertensive patient doctor prescribed antiadrenergic drug, first administration of which in therapeutic dose caused "first dose syncope". Which drug was most probably used?

A.   Metoprolol

B.   Atenolol

C.   Prazosin

D.   Reserpin

E.   Propranolol

9.    A 43 year-old male patient is suffering from hypertension. His blood pressure was successfully controlled by monotherapy with adrenoblocker. With time treatment was complicated with diarrhoea and impotence. The patient addressed his doctor and the drug was changed for another adrenoblocker. Which of adrenoblockers can cause above listed side effects?

A.   Metoprolol

B.    Salbutamol

С Propranolol

D.   Dobutamine

E.   Prazosin

10.   Which of the listed drugs is usually added to local anaesthetic to prolong its action and to decrease toxicity?

A.   Noradrenaline

B.   Ephedrine

C.   Adrenaline

D.   Reserpine

E.   Atropine

11.        For testing refraction of eye atropine was instilled into conjunctival sac. On completion of the procedure another cholinergic drug was used to counteract mydriasis and cycloplegia, caused by atropine. Point out this drug.

A.    Pilocarpine

B.    Lobeline

С Hyoscine (Scopolamine)

D.   Phenylephrine (Mesatonum)

E.    Pirenzepine

12.  In complex treatment of a child, suffering from cerebral palsy, a doctor decided to include anticholinesterase drug moder ately improving mental development. Choose this drug.

A.    Physostigmine

B.   Neostigmine (Proserinum)

C.   Galanthamine

D.   Pilocarpine

E.    Lobeline

13.  Administration of pirenzepine in patients with gastric peptic ulcer is not accompanied by numerous side effects characteristic for atropine and other M-cholinoblckers due to

A.   Inability to penetrate through blood brain barrier

B.    Selective inhibition of Mi-cholinoceptors
С. Inhibition of all types of M-cholinoceptors
D.   Inhibition of cholinesterase

E.   Significant protein binding

14.  It is known that administration of tubocurarine during surgery can enhance the development of postoperative paralyticileus. What is the mechanism of this side effect of tubocurarine?

A.   Inhibition of M-cholinoceptors

B.    Inhibition of cholinesterase
С. Ganglion blocking activity
D.   Stimulation of M-cholinoceptors

E.         Stimulation of both M- and N-cholinoceptors

 

15.  A 56-year-old patient with chronic alcoholism became aggressive. To abolish aggression chlorpromazine (aminazimim) was administered. What is the mechanism of antipsychotic effect of this drug?

A.   Blockade of reticular formation

B.   Blockade of dopamine D2-receptors
С. Blockade of M-cholinoceptors
D.   Blockade of a-adrenoceptors

E.   Blockade of [3-adrenoceptors

16.  To perform fundoscopy ophthalmologist instilled in the eye an agent capable of causing mydriasis without cycloplegia. Point out this agent.

A.   Phenylephrine (Mesatonum)

B.   Noradrenaline

С. Atropine

D. Pilocarpine

A. Isoprenaline (Isadrinum)

17.   A young woman with breast cancer after surgery was treated with a chemotherapeutic complex. At the very beginning of treatment the patient experienced much distressing nausea and vomiting. Choose the best agent to relieve patient's condition

A.   Hyoscine (Aeronum)

B.   Diphenhydramine (Dimedrolum)

C.   Validolum

D.   Chlorpromazine (Aminazinum)

E.   Metoclopramide

18.  Due to inhibition of COX aspirin exerts all the following effects except

A.   Anti-inflammatory

B.    Antiplatelet

C.   Increase in warfarin efficacy

D.   Antipyretic

E.   Analgesic

19.  Which of the following antiadrenergic drugs used in the treatment of hypertension is contraindicated in patients prone to bronchospasm?

A.   Prazosin

B.    Metoprolol

C.   Reserpine

D.   Atenolol

E.   Propranolol (Anaprilinum)

20.  Characteristic side effects associated with sulfa drugs are all the following except

A.   Allergic reaction

B.   Hypokalemia

C.   Crystallurea

D.   Agranulocytosis

E.   Kernicterus

21.  Patient with gastric peptic ulcer was treated with omeprazole. This agent is capable of decreasing in HCl production because it

A.   Neutralizes gastric acid

B.   Blocks Eb-histamine receptors

C.   Inhibits the H+, K+-ATPase proton pump

D.   Coats gastric mucosa

E.   Blocks muscarinic receptors

22. In the presence of a beta-blocker administration of adrenaline is most likely to cause:

A.   Hypoglycemia

B.    Hypokalemia

C.   Hypertension

D.   Hyperglycemia

E.   Hypotension.

23.        Very painful uterine contractions have been occurring in a pregnant woman at normal term. To relieve the woman's condition during labour, a doctor decided to use opioid (narcotic) analgesic. Which of the listed drags can be used in this case?

A.   Trimeperidine (Promedolum)

B.   Morphine

C.   Metamizole (Analginum)

D.   Papaverine

E.   Codeine

24. Point out antihypertensive agent that increases salts and H2O excretion and can cause hyperglycemia and uric acid retention?

A.   Nifedipine

B.   Propranolol
С. Prazosin
D.   Hydrochlorothiazide

E.   Acetazoleamide (Diacarbum)

25.  Which of the following conditions is alleviated by centrally acting anti-cholinergic drugs?

A.   Depression

B.   Multiple sclerosis

С. Mania

D.   Parkinsonism

E.   Psychosis

26.  Which of the following drugs is most likely to produce positive inotropic and negative chronotropic effects?

A.   Nitroglycerin

B.   Furosemide

C.   Diltiazem

D.   Procainamide

E.   Digoxin

27.        A hypertensive patient was treated with the drug suppressing the formation of angiotensin II and preventing degradation of bradykinine. Point out the drug realizing antihypertensive effect by these mechanisms.

A. Nifedipine
В. Guanethidine
C.   Clonidine

D.   Enalapril

E.   Propranolol

28. A hypertensive patient was fond of meat dishes and did not keep proper diet. In the course of complex antihypertensive treatment an acute attack of gout developed. Which of the following agents is responsible for worsening of patient condition?

A.   Hydrochlorothiazide

B.   Prazosin

C.   Allopurinol

D.   Acetazolamide

E.   Propranolol

29.  A 46-year-old patient with a history of epilepsy (grandmal) developed status epilepticus. Choose the drug to arrest convulsions.

A.   Sodium valproate

B.   Diazepam

C.   Levodopa

D.   Chlorpromazine

E.   Droperidol

30.  A 67-year-old man treated with hydrochlorothiazide for control of mild hypertension visited his doctor complaining of pains in joints. Which of the listed side effects is the most probable cause of patient's complains?

A.   Hyperglycemia

B.   Hyperuricemia

C.   Drug hypersensitivity

D.   Hyperkalemia

E.   Hypokalemia

 

31.  A 45-year-old woman presents to the emergency room with severe epigastric pain. On the base of patient examination and laboratory findings an acute pancreatitis is diagnosed. Which of the drugs is to be administered in this case?

A.   Pancreatin

B.   Mezym forte

C.   Contrycal

D.   Morphine

E.   Fentanyl

32.  On discontinuation of heparin treatment of patient with myocardial infarction administration of warfarin was started. This drug exerts its anticoagulant effect by

A.   Blocking calcium binding to clotting factors

B.   Forming a complex with clotting factors

C.   Breaking down thrombin

D.   Inhibiting of pro-clotting factor synthesis in the liver

E.   Depolymerization of fibrin

33.  A patient with angina pectoris was helping himself with nitroglycerin. One day the patient used nitroglycerin several times because of frequent episodes of pain. So as the last sublingual administration of nitroglycerin did not relieve pain, the patient addressed his doctor. Doctor advised him to withdraw nitroglycerin for 8 hours and prescribed another drug. After 8 hours the effect of nitroglycerin was restored. Which phenomenon did take place in this case?

A.   Increase in nitroglycerin metabolism

B.   Increase in protein binding

C.   Decrease of absorption

D.   Drug dependence

E.   Tolerance

34.        A patient in an unconscious state was admitted to the emergency room. Diabetic coma was diagnosed. Intravenous administration of regular insulin was performed. Which of listed agents in addition to insulin is commonly used intravenously to normalize patient's condition?

A.   Acarbose

B.   Tolbutamide
С. Glibenclamide
D.   Metformin

E.   Sodium bicarbonate

35. A patient with toothache was relieving his pain with help of metamizole (analginum). Point out another useful effect of this drug that contributes to the improvement of patient's condition

A.   Sedative effect

B.   Anti-inflammatory effect

C.   Antlplatelet effect

D.  Antioxidative effect

E.   Antimicrobial effect

36. The usage of acetylsalicylic acid resulted in occurrence of epigastric pain in patient. On examination of the patient gastric ulcer was revealed. What the mechanism is responsible for ulcerogenity of this drug?

A. Stimulation of pepsin secretion

B. Inhibition of prostaglandin synthesis

С Increase in bile production and its refluxr

D. Spasm of vessels

E. Spasm of gastric smooth muscles

37. A patient with bronchial asthma addresses his doctor with complaints about unpleasant palpitations that occur after usage of inhalation form of isoprenaline (isadrinum). What is the cause of this side effect?

A.   stimulation of ai-adrenoceptros

B.   stimulation of аг-adrenoceptros

C.   stimulation of pVadrenoceptros

D.   stimulation of p2-adrenoceptros

E.   inhibition of M-chlolinoceptors 

38. A patient with poisoning caused by carbon monoxide was administered directly acting analeptic drug. What medicine was used?

A.   Codeine

B.   Ephedrine

C.   Caffeine

D.   Atropine sulfate

E.    Lobeline

39. A patient with pinpoint pupils, sweating, salivation, abdominal cramps, disturbances in respiration was admitted to the emergency room. Poisoning with what substance is the most likely occurred?

A.   Non-narcotic analgesics

B.   Sedatives

C.  Narcotic analgesics

D.  M-cholinergic antagonists

E.   Muscarine

40. A teenager with a fracture of the hand was taken to the emergency room. To perform reposition of fractured bones it was necessary to relax skeletal muscle. For this purpose myorelaxant causing depolarization of the post synaptic membrane was administered. Which of the following agents was used?

A.   Pancuronium

B.   Atracurium

C.   D-tubocurarine

D.   Succinylcholine

E.   Neostigmine (Proserinum)

41. In the treatment of a patient suffering from congestive heart failure resistant to digitalis an adrenomimetic was used as an inotropic agent. Point out which of the following drugs was administered.

A.   Phenylephrine

B.   Partusisten

C.   Dobutamine

D.   Adrenaline

E.    Noradrenaline

42. A premature newborn was apnoic. Directly acting analeptic drug was given to restore breathing. What medicine was most probably administered to the patient?

A.   Aethimisolum

B.   Phenylephrine (Mesatonum)

C.   Adrenaline

D.   Atropine

E.   Lobeline

43. A 72-year woman suffering from angina pectoris was treat ed by propranolol (anaprilinium). On the background of the treatment cough with bronchospastic components was developed. Doctor replaced propranolol with metoprolol. This resulted in abolishing of respiratory disturbances. What is the reason for the beneficial effect of metoprolol?

A.   Block of M-cholinoceptors

B.   Absence of upon pYadrenoceptors

C.   Stimulating of M-cholinoceptors

D.   Inhibition of m-cholinireceptors

E.  Absence of action on a-adrenoceptors

44. Doctor prescribed selective ai-adrenoceptor blocker for treatment of hypertensive patient. Which of the following drugs belongs to this group?

A.   Metoprolol

B.    Phentolamine
С. Amiodarone
D.   Tropaphenum

E.   Prazosin

45.  A patient with angina pectoris was treated with a drug decreasing oxygen demands of myocardium. During treatment, the patient started to complain of coldness of extremities especially fingers. Which of the drug was used?

A.   Atenolol

B.   Propanol (anaprilin)

C.   Reserpine

D.   Prazosin

E.   Labetalol

46.  A patient, after the stroke, developed paralysis of the hand and leg. To restore movement of the paralyzed extremities the patient was treated with cholinomimetic. Which of the listed drugs was used for this purpose?

A.   Aceclidinum

B.   Pilocarpine

C.   Physostigmine

D.   Neostigmine (proserinum)

E.   Lobeline

47.  A patient suffering from gastric peptic ulcer was treated with cholinotropic drug selectively blocking Mi-cholinoceptors of parietal cells of gastric glands. Point out this drug?

A.   Atropine

B.   Plathyphylline

C.   Methacinum

D.   Pirenzepine

E.   Hyoscine (Scopolamine)

48. A 63 years patient with symptoms of collapse was admitted into emergency department. The doctor chose noradrenaline to overcome collapse. What mechanism is responsible for therapeutic effect of this drug?

A.   Activation of ai-adrenoceptors

B.   Activation of (32-adrenoceptors

C.   Activation of dopaminergic receptors

D.   Blockade of M-cholinoceptors

E.   Activation of serotonin receptors

49.  A 60 year-old woman addressed her doctor complaining of side effects, which appeared while treatment with chlorpromazine (aminazinum). She was troubled with tremor and disturbances of movements. What is the mechanism of these side effects?

A.  Activation of hyppocampus

B.  Inhibition of reticular formation (ai-adrenoceptors)

C. Inhibition of neostriatum (D2 receptors)

D. Inhibition of hypothalamus

E.  Inhibition of hyppocampus

50.  A 50 years old patient with chronic alcoholism became aggressive. To abolish aggression, chlorpromazine was administered intramuscularly. The patient's attempt to rise soon after an injection resulted in loss of consciousness. What is the probable cause of such complication?

A.   Blockade of reticular formation

B.   Disturbance of coronary blood circulation
С. Blockade of a- adrenoceptors
D.   Inhibition of hypothamus

E.   Blockade of M-cholinoceptors'

51.  To lance abscess a doctor performed local anaesthesia with a therapeutic dose of Procaine (Novocainamidum), but it was not sufficient. What was the cause of decrease in anaesthetic effect?

A.   Quick absorption of drug

B.   Quick metabolism of anaesthetic

C.   Alkaline medium

D.   Acidic pH of tissues

E.   Neutral medium

52.  A patient with Raynaud disease was treated with niphedipme. What is the mechanism of action of this drug?

A.   Blockade of p-adrenoceptors

B.   Blockade of a-adrenoceptors

C.   Decrease in neurotransmitter amount

D.   Calcium channels' blockade

E.   Blockade of central M-cholinoceptors

53.  A patient with initial form of hypertension complains of pain in heart and tachycardia. Which of the following drugs has to be used in the treatment of this patient?

A.   Phentolamine

B.   Dihydroergotamine

C.   Propranolol (Anaprilin)

D.   Prazoscin

E.   Guanethidine (Octadinum)

54. Patient having episodes of bronchial asthma in the past addressed his doctor with heart pains. An angina pectoris was diagnosed. The doctor decided to treat the patient with ;-adrenoblocker. Which of ;-adrenoblocker is not contraindi-cated in this case?

A.   Propranolol (Anaprilinum)

B.   Metoprolol

C.   Oxprenolol

D.   Pindolol

E.   Nadolol

55.  A surgeon is going to perform the operation under local anaesthesia. The probable duration of operation is more than 2 hours. In the past the patient was complaining for ventricular extrasystole. Which anaesthetic is reasonable to chose for local anaesthesia?

A.    Tetracaine (dicainum)

B.   Procaine (novocainum)

C. Benzocaine (anaesthesinum)

D.   Lidocaine

E.   Cocaine

56.       A dentist revealed that his patient is suffering from hyper-sensitivity to procaine. Which of the following agents may be used for local anaesthesia in this case?

A.   Benzocaine (anaesthesinum)

B.    Tramadol

C.   Tetracaine (Dicainum)

D.   Lidocaine

E.   Cocaine

57.  A psychiatrist was invited to a patient who made an attempt to commit suicide. Doctor diagnosed endogenous depression. Choose the most suitable drug for treatment of this patient.

A.   Nootropil (piracetam)

B.    Amytriptyline

C.   Sydnocarbum

D.   Ethymisolum

E.   Caffeine

58.  A patient had a stroke. Which of the listed drugs is necessary to include in the complex therapy in order to improve mental performance?

A.   Caffeine

B.   Piracetam

C.   Diazepam

D.   Phenazepam

E.   Amitryptiline

59.  What is the main mechanism by which amitriptyline in creases amount of catecholamines in CNS synapses?

A.   Increase in catecholamines release from presynaptic membrane

B.    Increase in catecholamines synthesis in presynaptic membrane

C.   Prevention of catecholamines degradation in the synapse

D.   Inhibition of neuronal re uptake of catecholamines

E.   Inhibition of MAO

60. After emotional stress patient was permanently in a condition of nervous tension and had poor sleep. Doctor prescribed him diazepam. Which of the listed effects of this drug is responsible for its clinical use?
A.    Hypotensive effect

B.   Analgesic effect

C.   Anticonvulsant

D.   Tranquilizing

E.    Anti psychotic

61. Antiepileptic drug, which prevents metabolism of GAB A, was included in complex therapy of patient with epilepsy (grand mal). Point out this drug.
A.    Phenytoin

B.   Phenobarbitone

C.   Carbamazepine

D.   Ethosuximide

E.    Sodium valproate

62.  A 60-year-old male is brought to emergency room. He is comatose and his pupils are constricted. Physician suspects opium overdose. What is the best drug to be administered?

A.    Flumazanil

B.   Calcium carbonate

C.   Sodium bicarbonate

D.   Naloxone

E.    Atropine

63.       A young boy with dislocation of shoulder joint is brought to emergency ward. It is necessary to relax skeletal muscles to set dislocated bone. For this purpose succinylcholine (dithylinum) is comonly used. But doctor avoids this agent due to his tory of death of one of patent's relatives after succinylcholine administration. What was the cause of death connected with succinylcholine?

 

A.   Hyperkalemia

B.   Hepatotoxicity

C.   Cardiac insufficiency

D.   Triggering of malignant hyperthermia

E.   Severe bronchospasm

64.  A patient given succinylcholine for skeletal muscle relaxation during an operation has not restored spontaneous respiration after operation. What must be used to restore the respiration?

A.   Carbogen

B.   Lobelin

С Neostigmine

D.   Blood transfusion

E.   Caffeine

65.  A 59-year-old man develops excessive salivation and sweating, diarrhea, and bradycardia while being treated with neostigmine for myasthenia gravis. Choose the drug to abolish above-mentioned side effects.

A.   Atropine

B.   Carbachol

С Edrophonium

D.   Adrenaline

E.   Pralidoxime

66.  The blood pressure of hypertensive patient is successfully controlled by administration of enalapril. Which mechanism is responsible for antihypertensive effect of this drug?

A.   Inhibition of peripheral ai-adrenoceptors

B.   Blockade of angiotensin II receptors

C.   Inhibition of renin release

D.   Inhibition of ACE

E.   ACE inhibition and stimulation of kallikrein–kinin system

67.  Metabolism can render pharmacological activity to some initially inert substances (pro-drug). Point out the substance, which is pro-drug, used for treatment of hypertension.

A.   Levodopa

B.   Enalapril

C.   Verapamil

D.   Reserpine

E.   Propranolol

68.  A 62-year-old patient, prone to bronchoconstriction, addressed his doctor with complaints of tachyarrhythmia troubling him several times a day. The doctor prescribed anaprilin (propranolol). Administration of this drug provoked severe attack of bronchospasm. What is the mechanism of this side effect?

A.   Stimulation of Mi-cholinoceptors

B.   Inhibition of a-adrenoceptors

C.   Inhibition of P2-adrenoceptors

D.   Increase in n. vagus tone

E.   Stimulation of leukotriene release

69.  A pregnant woman developed rhythmic uterine contractions at the physiological term of delivery. But contractions were not progressing in force and frequency. Choose the drug for stimulation of uterine contraction.

A.   Oxytocin

B.   Ergometrine

C.   Partusisten

D.   Physostigmine

E.   Castor oil

70.  In complex therapy of bronchial asthma myotropic spasmolytic drug was added. Soon after its usage, nervousness and sleep disturbances occurred. Which of the following drugs can cause above-mentioned side effect?

A.   Papaverine

B.   Platyphilline

C.   Aminophylline

D.   Drotaverine

E.   Ephedrine

71.  To maintain normal sinus rhythm in a patient with atrial fibrillation the doctor prescribed an antiarrhythmic drug. After laboratory testing of thyroid function administration of this drug was withdrawn. What drug was initially prescribed?

A.   Verapamil

B.   Amiodarone

C.   Quinidine

D.   Procainamide

E.   Lidocaine

72.  A car driver has got involved in an accident and was admited to emergancy department. Surgical invasion in abdominal cavity was successfully performed, but postoperative period was complicated by peritonitis. Bacterial analysis revealed Pseudomonas aeruginosa. For treatment of this patient any of antibiotics leasted below can be used with axception of

A.   Azlocillin

B.   Genamycine

C.   Cefotaxim

D.   Imipenem (Tienam)

E.   Doxycycline

73.  A 6-year boy was admitted to hospital with pneumonia. Treatment with amoxicillin was not effective. Bacterial analysis revealed Micoplasma pneumoniae. Choose the most suitable drug for treatment of this child.

A.   Tetracycline

B.   Azithromycin

C.   Bicillin-5

D.   Nystatin

E.   Oxacillin

74.  A 20 years old man with gonorrhea was treated with preparation of natural penicillin. His condition improved, but 1 week later the patient was still complaining of a persistent urethral discharge and pain on urination. Laboratory test revealed chlamydia in discharge. Which of the listed drugs effective both in case of gonorrhea and chlamidial infection must be used for further treatment?

A.   Amoxicillin

B.   Doxycycline

C.   Oxacillin

D.   Gentamycin

E.   Streptomycin

75.  A 5 year-old child was suffering from bronchitis, accompanied by a productive cough with thick sputum. In addition to antimicrobial treatment a mucolytic drug was prescribed. This drug was especially beneficial for the child due to its ability to stimulate production of surfactant. Point out this drug.

A.    Codeine

B.   Ambroxolum

C.   Oxeladine

D.   Ethylmorphine

E.    Potassium iodide

76.  Patient suffering from tuberculosis was treated with isoniazid. In the course of treatment peripheral neuritis was developed. What is the mechanism of this side effect?

A.   Direct toxic effect of drug on peripheral nerves

B.   Inhibition of myoneural junctions

C.   Interference with pyridoxine metabolism

D.   Interference with folic acid synthesis

E.   Inhibition of sodium channels

77.        Patient with tuberculosis was on the complex treatment including antibiotics. At the end of the first course the doctor noticed significant decrease in patient hearing. Which of the following drugs can cause such side effect?

A. Isoniazid

B. Rifampicin

С Streptomycin

D.  Paraaminosalicylic acid

E.   Pirazinamide

78. Patient with phenobarbital poisoning was presented to emergency department. To promote kidney excretion of poi­son sodium bicarbonate was administered intravenously. What mechanism is responsible for an increase in barbiturate excre­tion?
A.   Increase in polarity of barbiturate

B.   Increase in fat solubility of barbiturate

C.   Increase in barbiturate reabsorption

D.   Increase in rate of glomerular filtration

E.   Decrease in protein binding

79. Hypertensive patient was treated with the drug that decreases vascular tone. His treatment was complicated by persistent dry cough. Which drug most probably was used?
A.   Papaverine

B.   Phentolamine

С. Lisinopril

D.  Prazosin 

E.   Clonidine

80. One of the problems in the treatment of tuberculosis is caused by existence of metabolically dormant forms of myco-bacteria. Which of the drugs is effective against all subpopu-lations of Mycobacteria tuberculosis and causes sterilizing effect?

A.   Streptomycin

B.   Isoniazid

C.  Kanamycin

D.  Rifampicin

E.   Paraaminosalicylic acid

81. A patient suffering from hypertension was treated with hy-drochlorothiazide. With time he addressed doctor complaining of worsening of his condition. On examination of the patient hypokalemia was diagnosed. Choose the drug, which has to be added aiming at enhancement of diuretic effect and abolishing of hypokalemia.
A.   Acetazolamide

B.   Furosemide

C.   Ethacrynic acid

D.   Spironolactone

E.   Chlorothiazide

82.  A 7-year-old boy with bacterial meningitis was treated with long acting cephalosporin of the III generation. What the drug was used for treatment of this child?

A.   Carbenicilin

B.   Ceftriaxone 

C.   Cefalexin

D.   Gentamycin

E.   Doxycycline

83.  A patient with moderate hypertension was treated with the drug that realizes its effect by decrease in noradrenaline release from sympathetic nerve endings. While treatment patient experienced drowsiness. What the drug was used?

A.   Prazosin

B.   Reserpin

C.   Drotaverine

D.   Atenolol

E.    Dichlorothiazide

84. The tuberculous patient was treated with combination of antituberculous drugs, including isoniazid. Which drug must be added to prevent neurological side effects of isoniazid?

A.  Streptomycin

B.  PASA

C.  Rifampicin

D.  Pyridoxine

E.   Ascorbic acid

85. The patient with arthritis was treated with prednisolone for a long period. Doctor decided to discontinue prednisolone administration and change it by another drug. What is the right way of this drug discontinuation?

A.  It must be preceded by corticotropin administration

B.   It must be done in a vary short time

С. It must be preceded by administration of ADH

D.  It must be performed on the background of mineralocortcoid administration

E.   It must be preceded by growth hormone administration

86. A little boy of 7 years old was complaining of thirst and frequent urination. On examination hyperglycaemia was revealed and diabetes mellitus was diagnosed. Which of antidi-abetic drugs most probably can be used for treatment of this patient?
A.   Acarbose

B.   Chlorpropamide

С. Insulin

D.  Metformin

E.   Glibenclamide

87. The treatment of a patient suffering from pneumonia with ciprofloxacine was not effective, due to this the drug was changed for potent aminoglycoside antibiotic. Point out this antibiotic

A.  Ampicillin

B.   Amikacin

C.  Azithromycin

D.  Ceftriaxone

E.   Tetracycline

88.  An 11 year-old boy with pneumonia was treated with amoxicillin. What is the mechanism of action of this drug?

A.   Disturbances of structure and function of cell membrane

B.    Inhibition of cell wall synthesis
С. Inhibition of protein synthesis
D.   Inhibition of nucleic acid synthesis

E.   Inhibition of folic acid metabolism

89.  Patient suffering from tachyarrhythmia was treated with calcium channel blocker. What drug was used?

A.   Niphedipine

B.   Verapamil

C.   Labetolol

D.   Alprenolol

E.   Nicardipine

90.  Choose the inotropic drug for treatment of patient suffering from congestive heart failure, not responding to digitalis.

A.   Phenylephrine

B.  Dobutamine

C.  Clonidine

D.  Noradrenaline

E.   Salbutamol

91.  Severe attack of bronchospasm and cough occurred in a patient with bronchial asthma. Choose the best drug for quick relief of the patient condition.

A.   Ipratropium bromide

B.  Orciprenaline sulfate

C.  Atropine

D.  Adrenaline

E.   Noradrenaline

92.  A 52-year-old patient with supraventricular tachyarrhythmia was using antiarrhythmic drug of class III. For a long period it maintained the normal cardiac rhythm, but with time dispnoe started to occur while going upstairs. Patient addressed doctor. The examination revealed pulmonary sclerosis. Which of the antiarrhythmic drug can cause such side effect?

A.   Verapamil

B.  Amiodarone

C.  Bretylium

D.  Lidocaine

E.   Procainamide

93.  A patient addressed doctor with complaints of heartburn often troubling him. On examination ulcerative esophagitis was diagnosed and inhibitor of proton pomp was prescribed. Which of the following drugs was prescribed?

A.    Cimetidine

B.   Ranitidine

C.   Omeprazole

D.   Misoprostol

E.   Metronidazole

94.  A patient with acute poisoning was admitted to emergency department. It was established that poisonous substance was excreted by kidney. Choose the best diuretic for forced diuresis.

A.   Acetazolamide

B.   Amiloride

C.   Spironolactone

D.   Furosemide

E.   Hydrochlorothiazide

95.  For treatment of hypertensive patient doctor prescribed captopril, but soon patient addressed doctor, complaining of dry cough and rashes. Doctor substituted captopril for losartan. What is the mechanism of the last drug action?

A.   Inhibition of renin release

B.   Inhibition of ACE

C.   Inhibition of angiotensinogen conversion to angiotensin I

D.   Blockade of angiotensin II receptors

E.   Increase in bradykinin level

96. A 60 year-old patient with angina pectoris visited her doctor for routine examination. Blood sampling revealed elevated level of cholesterol in the plasma. Due to this antisclerotic drug was added to antianginal therapy. This drug enhanses lipopro-tein lipase synthesis and dicreases hepatic synthesis of triglyc-erides. What the drug was prescribed?
A.   Nicotinic acid

B.   Probucol

C.   Lovastatin

D.   Fenofibrate

E.   Colestipol

97. A patient with clinical manifestations of malaria was prescribed erythrocytic schizontocidal fast acting drug, which in addition to antimalarial effect has anti-inflammatory property and is used in the treatment of rheumatoid arthritis and lupus erhythematosus. Point out this drug.
A.    Pyrimethamine

B.   Chloroquine (Chingaminum)

C.   Trimetoprim

D.   Chloroguanide

E.    Sulfadimethoxin

98. To prevent the onset of myocardial infarction in a patient with angina pectoris aspirin was used. Due to which of listed effects aspirin is beneficial in this case?

A.   Antiinflammatory

B.   Antiplatelet

C.   Analgesic

D. Antipyretic

E. Ulcerogenic

99. A young women with 6 months pregnancy visited her doctor complaining of periodical slight contractions of uterus To prevent premature labour doctor prescribed partusisten (fenotrrol). What is the mechanism of action of this drug?

A.    Stimulation of pYadrenoceptors

B.   Inhibition of p2-adrenoceptors

С. Stimulation of ai-adrenoceptors

D. Inhibition of ai-adrenoceptors

E. Stimulation of M-cholinoceptors

100. Antiprotozal agent of wide spectrum was included in complex treatment of patient with gastric peptic ulcer. Doctor warned patient about prohibition of alcohol usage during treatment with this drug. What the drug was used?

A.   Chloramphenicol

B.  Metronidazole

C.  Cotrimoxazole

D.  Chloroquine

E.   Praziquantel

101. A young women was diagnosed atopic dermatitis. She asked her doctor to prescribe the drug, which does not interfere with driving her car. The doctor prescribed the drug that belongs to 2nd generation of antihistaminics. Point out this drug

A.   Cromolin-sodium

B.  Diphenhydramine (Dimedrolum)

C.  Loratadine

D. Famotidine

E. Prednisolone

102. Digoxin in tablets was prescribed to patient with chronic congestive heart failure. After 1 month of treatment decrease in heart rate was noted; doctor advised the patient to continue treatment with lower dose of digoxin. In spite of this the bradycardia was soon transformed into A-V-block. Choose the necessary drug for abolishing of this manifestation of glycoside toxicity.

A.   Potassium chloride

B.  Phenytoin

C.  Atropine

D.  Lidocaine

E.   Propranolol

103.    A patient with myocardial infarction was treated with intravenous infusion of heparin. What is the goal of this drug administration?

A.   To cause the lysis of thrombus directly

B.  To transform plasminogen into plasmin

C.  To prevent further thrombosis

D.  To prevent platelets activation

E.   To decrease the area of necrosis

104.    A patient with a history of angina pectoris and high plasma cholesterol level was prescribed phenofibrate. What is the mechanism of action of this drug?

A.   Activation of lipoprotein lipase

B.  Inhibition of lipoprotein lipase

C.  Inhibition of hydroxymethyl glutaryl coenzyme A

D.  Inhibition of LDL oxidation

E.   Bile acid sequestration

105.    A 40 year-old woman addressed her doctor complaining of frequent and painful urination. Uretritis was diagnosed and fluorinated quinolone derivative was prescribed. Point out this drug.

A.   Ceftriaxone

B.  Ciprofloxacin

C.  Nitroxoline

D.  Furazolidone

E.   Cotrimoxazole

106. It is known that morphine can cause a shift of blood from pulmonary to systemic circuit. It results in lowering of resistance in pulmonary vascular bed. In which case it may be used?

A.   Bronchitis

B.  Pneumonia

C.  Pulmonary oedema

D.  Bronchiectatic disease

E. Emphysema

107. A 72 year-old patient addressed doctor complaining of decrease in appetite, episodes of nausea and vomiting, poor sleep. These disturbances started to trouble him for last 2 weeks. Analysis revealed ascariasis. Doctor prescribed the drug, which in addition to anthelminthic action exerts immu-nostimulating effect. Point out this drug.
A.   Mebendasole

B.  Pyrantel

C.  Levamisole

D.  Piperazine

E.  Praziquantel

108. Regular medical examination of schoolchildren revealed a 7-year boy infected with Enterobius vermicularis. For his treatment mebendazole was prescribed. What is the mechanism of this drug action?

A.  It causes persistent depolarization and spastic paralysis of worm

B.  It blocks carbohydrate metabolism and inhibits p- tubulin polymerization

C.  It causes leakage of intracellular calcium and paralysis of parasite

D.  It causes hyperpolarization of worm's muscle and its relaxation

E.  It alters the surface structures of parasite and kills it

109.    Surgical treatment of benign tumor of prostate in 67-year patient was postponed; instead pharmacotherapy with adrenergic drag was started. Point out which of the drugs was most probably used.

A.   Adrenaline

B.  Ephedrine

C.  Prazosine

D.  Propranolol (Anaprilinum)

E.  Atenolol

110.    A young man was taken to emergency department with numerous traumas of chest and head. Anesthesiologist proposed to inject morphine to relieve patient's condition, but traumatologist rejected proposition of his colleague. Why morphine is contraindicated in this case?

A.   It increases intracranial pressure

B.  It stimulates vagal center

C.  It decreases intraocular pressure

D.  It causes miosis

E.  It depresses center of cough reflex

111.    Point out the neuroleptic that is most commonly used in neuroleptanalgesia.

A.   Chlorpromazine

B.  Droperidol

C.  Diazepam

D.  Chlorprotixene

E.  Sulpiride

112.      Patient with gastric peptic ulcer addressed his doctor. After examination doctor prescribed famotidine aiming at inhibition of gastric acid secretion. What is the mechanism of this drag action?

A. Inhibition of proton pump

B.  Neutralization of gastric acid

C.  Prevention of histamine release

D.  Blockade of Hi histamine receptors

E.  Blockade of H2 histamine receptors

113. Doctor visited a 5-year-old child with fever and com­plaints of headache. Doctor suspected the onset of viral infec­tion. To relieve patient's condition doctor prescribed non-opi-oid analgesic, which additionally exerts antipyretic effect but lacks anti-inflammatory action. Point out the prescribed drug

A.   Metamizole (Analginum)

B.  Celecoxib

С. Aspirin

D.  Acetaminophen (Paracetamol)

E.  Diclophenac-sodium

114. Deficiency in dopamine production by neurons of strio-pallidal system is considered to be one of the main causes of Parkinson's disease. Point out the drug used for replacement therapy of this disease
A.   Atropine

B.  Dopamine

C.  Levodopa

D.  Carbidopa

E.   Amantadine

115. Patient suffering from pernicious anemia is treated with folic acid. Which agent is to be added to make effective the treatment of this disease?

A.   Retinoli acetas

B.  Cyancobalamin
С Thiamine bromide

D.  Retabolil

E.   Insulin

 

 

 

Answers

1-C; 2-C; 3-Е; 4-C; 5-C; 6-Е; 7-B; 8-C; 9-Е; 10-C 11-A; 12-C; 13-B; 14-C; 15-B; 16-A; 17-Е; 18-С; 19-Е; 20-В; 21-C; 22-C; 23-A; 24-D; 25-D; 26-E; 27-D; 28-A; 29-B; 30-B; 31-C; 32-D; 33-E; 34-E; 35-B; 36-B; 37- C; 38-C; 39-E; 40-D; 41-C; 42-A; 43-B; 44-E; 45-B; 46-D; 47-D; 48-A; 49-C; 50-C; 51-D; 52-D; 53-C; 54-B; 55-D; 56-D; 57-B; 58-B; 59-D; 60-D; 61-E; 62-D; 63-D; 64-D; 65-A; 66-E; 67-B; 68- C; 69-A; 70-C; 71-B; 72-E; 73-B; 74-B; 75-B; 76-C; 77-C; 78-A; 79-C; 80-D; 81-D 82-B; 83-B; 84-D; 85-A; 86-C; 87-B; 88-B; 89-B; 90-B; 91-D; 92-B; 93-C; 94-D; 95-D; 96-C; 97-B; 98-B; 99-A; 100-B; 101-C; 102-C; 103-C; 104-A; 105-B; 106-C; 107-C; 108-B; 109-C; 110-A; 111-B; 112-E; 113- D; 114- C; 115 -B.